The Significance of Lysosome in the Diagnosis and Subclassification of Alzheimer’s Disease

Lysosomes are the main degradation organelles in eukaryotic cells, and their dysfunction is closely related to Alzheimer’s disease (AD). Our goal identify lysosomal molecular subtype of AD explore mechanisms. By differential analysis, 50 differentially expressed genes were identified. R-package “ROCR” was used calculate ROC curves AUC values for genes. “ConsensusClusterPlus” consistent clustering data set. The contents 28 kinds immune cells samples calculated using “GSVA”. R package “limma” analyze differences autophagy “WGCNA” carried out weighted co-expression network analysis. Two lysosomes subtypes identified cohort by lysosome diagnostics molecular, known as cluster 1/2. results showed that 13 significantly different between 1 2. A total 76 autopaghy enrichment analysis key module mainly concentrated synapses. We two based on gene expressions, preliminarily revealing heterogeneity may be caused lysosomes. role